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The 1993 New England Journal of Medicine study on tretinoin showed an 80% increase in Type I collagen formation in photodamaged skin after 10 to 12 months of treatment

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The preclinical data place GHK-Cus influence primarily in the proliferation and remodeling phases recruiting and activating fibroblasts, feeding matrix synthesis, supporting new-vessel formation to perfuse the growing tissue, and then enabling proper cross-linking so the new matrix gains strength

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The BPC-157 research guide explores this in depth